Dehydroepiandrosterone: Is There a Role for Replacement?
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چکیده
منابع مشابه
Dehydroepiandrosterone: is there a role for replacement?
Dehydroepiandrosterone (DHEA) and its sulfated ester are found in high concentrations in the plasma; however, their role in normal human physiology, other than as precursors for sex hormones, remains incompletely defined. Studies of rodent models have shown that these hormones have beneficial effects on a wide variety of conditions, such as diabetes, obesity, immune function, atherosclerosis, a...
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Dehydroepiandrosterone (DHEA) and its sulphated derivative DHEAS are the most abundant circulating steroids, and are derived from the zona reticularis of the adrenal cortex. The foetal adrenals synthesise signi®cant quantities of DHEA, but production of this steroid falls postnatally. The onset of adrenarche (between the ages of 6 and 8 years) is characterised by increasing biosynthesis of DHEA...
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ژورنال
عنوان ژورنال: Mayo Clinic Proceedings
سال: 2003
ISSN: 0025-6196
DOI: 10.4065/78.10.1257